Normalization of Cardiac Structural dimension and Function to Body Surface Area in South East Nigeria Children.

BACKGROUND: Standardizing cardiac valve structures and function to body surface area will help the clinician and surgeons in decision-making. AIM: To evaluate the z-scores of the sizes of cardiac structures and function and to present them in Gaussian curves and reference values. MATERIALS AND METHODS: This was a cross-sectional study that involved 300 apparently healthy children. This study was performed among healthy children from birth to 18 years. Children with a normal echocardiogram, those with no chronic illness, no congenital heart defect, and no acquired heart defect were included in the study. RESULT: The majority fell within the normal limits, as shown in the Gaussian curves. For instance, 40 (13.3%) of atrioventricular (AV) valve diameters were +1 Z-score above the normal, and only 5 (1.7%) were +2 Z-score above the normal. About 9.3% (28/300) had below -2 Z-score below normal, while only 5% had -1 Z-score below normal. Similarly, the left ventricular function z-scores were also derived at -3 Z-scores to +3 Z-scores. The standard reference values were compared with the results obtained from our Z score values. There was no significant difference noted in the Z-scores. P values ranged from 0.07 to 0.84 for all the cardiac structures except for gender, where Z-scores of the mitral valve and left pulmonary artery varied significantly (P = 0.02). CONCLUSION: Reference values of cardiac structure and function were presented using Z scores, and we noted no significant difference when compared with the Western standard values except for the mitral valve and left pulmonary artery.

Echocardiographic Comparison of Left Ventricular Systolic Function and Aortic Blood Flow Velocimetry in Children with Ventricular Septal Defect.

BACKGROUND: The assessments of left ventricular (LV) longitudinal systolic dynamics in children with ventricular septal defect (VSD) have achieved a major milestone in the evaluation of LV systolic function. OBJECTIVES: This study aims to evaluate the LV function, LV mass (LVM), and the descending aorta blood flow in children with VSD compared to that obtained in age and sex-matched controls. RESULTS: The mean LVM of the control, 113.5 ± 123.9 was higher than that of those who had VSD, 75.8 ± 83.9, and the difference in mean was found to be statistically significant (Mann-Whitney U = 2.322, P = 0.022). The mean EF of the control, 67.9 ± 10.3 was comparable to that of those with VSD, 65.6 ± 13.9, (Student's t = 1.223, P = 0.223). Similarly, the mean descending aorta blood flow of control, 1.6 ± 2.2 was comparable to that of those with VSD, 3.9 ± 16.1, (Mann-Whitney U = 1.002, P = 0.321). There was a very weak positive correlation between LVM and descending aorta blood flow among the subjects (n = 85, r = 0.117, P = 0.425). There was a very weak negative correlation between LVM and descending aorta blood flow among control. (n = 85, r = -0.065, P = 0.609). CONCLUSION: The LVM among children with VSD is lower than controls but there is no difference between LV function in subjects and controls. There is a linear increase of LVM with descending aorta blood flow.

Eisenmenger Syndrome: A Revisit of a Hidden but Catastrophic Disease.

BACKGROUND: Eisenmenger syndrome (ES) is a rare condition seen in children with congenital heart disease (CHD). It is characterized by raised pulmonary vascular resistance (PVR) arising from a shunt reversal with the presence of desaturated blood in the systemic circulation. Proper timing and early intervention in children with congenital heart disease have made the syndrome a rare occurrence. However, this cannot be said in developing countries where facilities for the diagnosis and management of children with congenital heart disease are not optimal. OBJECTIVES: The aim of this narrative review is to highlight the importance of early diagnosis and to review the new techniques in the evaluation of children with ES. It also highlights in a snapshot the state of management of ES in a developing country. METHODS: A search for published data on ES was done through several search engines such as Pubmed, google scholar citation, systematic reviews, and meta-analysis. This involves research done over the past 30 years. Keywords such as Eisenmenger'syndrome, 'congenital heart defect', 'Pulmonary hypertension', 'catherterization', 'echocardiography', and children' were used. RESULTS: This review shows the new technique in the diagnosis, aetio-pathogenesis, management and treatment of children with ES in-depth descriptive analysis and new advances in the management of children with ES. CONCLUSION: Eisenmenger syndrome is a preventable disease that can be curbed by early diagnosis and treatment of children with congenital heart disease, especially in the developing world.

CONTEXTE: Le syndrome d'Eisenmenger (SE) est une affection rare observée chez les enfants atteints de cardiopathie congénitale. Il se caractérise par une augmentation de la résistance vasculaire pulmonaire (RVP) due à l'inversion d'un shunt et à la présence de sang désaturé dans la circulation systémique. Le syndrome est devenu rare chez les enfants atteints de cardiopathie congénitale grâce à un choix judicieux du moment et à une intervention précoce. Toutefois, il n'en va pas de même dans les pays en développement où les moyens de diagnostic et de prise en charge des enfants atteints de cardiopathies congénitales ne sont pas optimaux. OBJECTIFS: L'objectif de cette revue narrative est de souligner l'importance d'un diagnostic précoce et de passer en revue les nouvelles techniques d'évaluation des enfants atteints de SE. Elle met également en lumière, sous forme d'un instantané, l'état de la prise en charge de l'ES dans un pays en développement. MÉTHODES: Une recherche de données publiées sur l'ES a été effectuée à l'aide de plusieurs moteurs de recherche tels que Pubmed, google scholar citation, revues systématiques et méta-analyses. Il s'agit de recherches effectuées au cours des 30 dernières années. Des mots clés tels que "syndrome d'Eisenmenger", "malformation cardiaque congénitale", "hypertension pulmonaire", "cathétérisme", "échocardiographie" et "enfants" ont été utilisés. RÉSULTATS: Cette revue présente les nouvelles techniques de diagnostic, d'étio-pathogénie, de prise en charge et de traitement des enfants atteints de SE, ainsi qu'une analyse descriptive approfondie et les nouvelles avancées dans la prise en charge des enfants atteints de SE. CONCLUSION: Le syndrome d'Eisenmenger est une maladie évitable qui peut être enrayée par un diagnostic et un traitement précoces des enfants atteints de cardiopathies congénitales, en particulier dans les pays en développement. Mots-clés: Syndrome d'Eisenmenger; Enfants; Cardiopathie congénitale; Hhypertension pulmonaire; Prise en charge.

Pattern and predictors of internet addiction among secondary school adolescents in Enugu, Nigeria.

Background: Internet addiction has negative effects on adolescents. These range from psychological and social impediments to school absenteeism. Aim: To ascertain the pattern of Internet addiction and the factors that predict Internet addiction among secondary school adolescents in southeast Nigeria. Subjects and Methods: This was a cross-sectional study that involved 796 secondary school adolescents drawn from six secondary schools in Enugu, Nigeria. The data were analyzed using IBM Statistical Package for Social Sciences (SPSS) software. Results: The highest proportion of the respondents (36.3%) had a moderate level of Internet addiction, while the least proportion (2.1%) had severe dependence on the Internet. Adolescents who were less than 15 years of age have 1.1 odds of having Internet addiction when compared to those who were 20 years and above (AOR = 1.1; 95% CI: 0.4-2.8). The respondents who were of the low socioeconomic class were 1.2 times more likely to have Internet addiction when compared with those in the high socioeconomic class (AOR = 1.2; 95% CI: 0.9-1.7). About 20.1% of adolescents were always depressed when they are not using the Internet, while 16.3% of adolescents who were addicted to the Internet developed insomnia. Conclusion: There is a rising prevalence of Internet addiction among secondary school adolescents. Younger adolescents tend to be more addicted to the Internet than their older counterparts. A small number of them had severe Internet addiction. A subpopulation of adolescents who were addicted to the Internet presents with depression and sleep disorders.

Pulmonary Hypertension in Children with Ventricular Septal Defects.

BACKGROUND: Ventricular septal defect (VSD) is a common congenital heart disease which could be complicated with pulmonary hypertension (PH). OBJECTIVES: This study sought to establish the relationship between severity of PH and size of VSD and age. METHODS: This is a descriptive study where one hundred and fiftyone children aged 3 months to 18 years with echocardiographically confirmed VSD were studied. Pulmonary hypertension (PH) was determined using the tricuspid regurgitation jet velocity with a cutoff of systolic pulmonary arterial pressure (sPAP) at >25mmHg. Severity of pulmonary hypertension was classified into mild (25-50mg Hg); moderate, (51-60mm Hg) and severe ≥ 60mm Hg. Data were analysed using the SPSS version 25. RESULTS: Majority 52.9% had mild PH while 17.6% had severe PH. Mild PH (χ2=15.513, p=0.004) was found among 66.7% of those with small-sized VSD, 42% of those with moderate-sized VSD and 57.1% of those with large-sized VSD. There was a weak positive correlation between PH and size of VSD (n=132, r=0.320, p<0.001). For one-unit increase in age (in months), PH was noted to decrease by 0.030 (B= -0.030, 95%CI: -0.090- 0.030) and for a unit increase in size (mm) of VSD, PH increased by 1.681 units (B=1.681, 95%CI: 0.798- 2.563). CONCLUSION: There was a linear increase in pulmonary hypertension with increase in the size of ventricular-septal defect and decrease in the age of children with VSD. Age and VSD size were significant predictors of PH severity in children with VSD. All sizes of VSD are associated with pulmonary hypertension. A unit increase in age (in months), caused a decrease of PH by 0.030units and a unit increase in size (mm) of VSD resulted in an increased PH by 1.681 units.

CONTEXTE: La communication interventriculaire (CIP) est une cardiopathie congénitale courante qui peut se compliquer d'hypertension pulmonaire (HP). OBJECTIFS: Cette étude visait à établir la relation entre la sévérité de l'HTP et la taille de la communication interventriculaire et l'âge. MÉTHODES: Il s'agit d'une étude descriptive dans laquelle cent cinquante et un enfants âgés de 3 mois à 18 ans avec une VSD confirmée par échocardiographie ont été étudiés. L'hypertension pulmonaire (HP) a été déterminée en utilisant la vitesse du jet de régurgitation tricuspide avec un seuil de pression artérielle pulmonaire systolique (PAPS) à >25mmHg. La gravité de l'hypertension pulmonaire a été classée en légère (25-50mg Hg) ; modérée, (51-60mm Hg) et sévère ≥60mm Hg. Les données ont été analysées à l'aide du SPSS version 25. RÉSULTATS: La majorité 52,9% avait un PH léger tandis que 17,6% avaient un PH sévère. Un PH léger (χ2=15,513, p=0,004) a été trouvé chez 66,7% de ceux qui avaient une VSD de petite taille, 42% de ceux qui avaient une VSD de taille modérée et 57,1% de ceux qui avaient une VSD de grande taille. Il y avait une faible corrélation positive entre le PH et la taille de la VSD (n=132, r=0,320, p<0,001). Pour une augmentation d'une unité de l'âge (en mois), le PH a diminué de 0,030 (B= -0,030, 95%CI : -0,090- 0,030) et pour une augmentation d'une unité de la taille (mm) de la VSD, le PH a augmenté de 1,681 unités (B=1,681, 95%CI : 0,798- 2,563). CONCLUSION: Il y avait une augmentation linéaire de l'hypertension pulmonaire avec l'augmentation de la taille du défaut ventriculaireseptal et l'augmentation de l'âge des enfants avec VSD. L'âge et la taille de l'anomalie ventriculaire-septale étaient des prédicteurs significatifs de la gravité de l'hypertension pulmonaire chez les enfants atteints d'une anomalie ventriculaire-septale. Toutes les tailles de VSD sont associées à l'hypertension pulmonaire. Une augmentation unitaire de l'âge (en mois) a entraîné une diminution de l'HTP de 0,030 unité et une augmentation unitaire de la taille (mm) de la CIA a entraîné une augmentation de l'HTP de 1,681 unité. MOTS CLÉS: hypertension pulmonaire ; VSD ; taille ; âge.

The impact of body mass index on left ventricular mass index, right ventricular function, and cardiac dimension of children with sickle cell anemia in Enugu City.

BACKGROUND: Body mass index is a major determinant of cardiac annular valvar dimension and left ventricular mass index in children with sickle cell anemia. OBJECTIVES: The study is aimed at ascertaining the impact of Body Mass Index on Left ventricular mass index, right ventricular function and cardiac dimension of children with sickle cell anemia. METHODS: A case control study in which echocardiographic measurement of cardiac function and structures were ascertained among children with sickle cell anemia compared with hemoglobin AA genotype. RESULTS: There were 51 subjects and 50 controls. The subjects comprised 54.9% males and controls, 52.0% male. There was a strong positive correlation between BMI and most cardiac structure diameters among children with normal hemoglobin genotype (Pearson's correlation coefficient value, P < 0.001) There was also statistically significant positive correlation between BMI and LV mass among the subjects (n = 50, r = 0.5, P < 0.001). There was significant positive correlation between BMI and TAPSE in both subjects and controls as well as between BMI and RVSP among the subjects, but not the controls (p < 0.001). There was no significant difference in the number with left ventricular hypertrophy (LVH) based on their nutritional status (n = 51, χ^2 = 7.03, P = 0.32). The BMI correlated negatively with left ventricular mass index (LVMI) among the subjects, but the correlation was not statistically significant (r = -0.1, P = 0.53). CONCLUSION: There was significant positive correlation between BMI and TAPSE in both subjects and controls as well as between BMI and RVSP among the subjects, but not the controls. Body mass index correlated negatively with left ventricular mass index (LVMI) among the subjects.

Prevalence of psychological workplace violence among employees of a public tertiary health facility in Enugu, Southeast Nigeria.

BACKGROUND: Psychological violence is the most common form of workplace violence (WPV) that can affect job performance and health of the workers. AIMS: This study sought to determine the prevalence of psychological WPV among employees working in a tertiary health institution in a South-eastern state of Nigeria. METHODS: A descriptive cross-sectional study done in 2018 among healthcare workers at the University of Nigeria Teaching Hospital Enugu State using a pretested self-administered questionnaire adapted from Workplace Violence in the Health Sector Country Case Study Questionnaire. Proportionate sampling method was used to select 412 respondents. Data were analyzed with SPSS version 23 using Chi-square test of significance and P value set at 0.05. RESULTS: Prevalence of psychological violence among the participants was 49.7%. Verbal abuse was the most form of psychological violence experienced 168 (40.8%) followed by bullying 29 (7.0%) while sexual abuse was reported by 8 (1.9%). Majority 114 (55.6%) of the perpetrators of the psychological violence were patient's relative, whereas 48 (23.4%) were staff members. In response to the violence, 58 (28.6%) of the healthcare workers took no action, while only 2 (1%) completed incident/accident form. Bullying was statistically significantly higher in healthcare workers who have spent less than 10 years (χ2 = 3.978 P = 0.046). There was a significant association between verbal abuse and frequent interaction with patients (χ2 = 4.757, P = 0.029). CONCLUSION: This study has shown that the prevalence of psychological WPV was high among healthcare workers in University of Nigeria Teaching Hospital, Enugu State. Therefore, there is need for the hospital management to develop policy interventions specific to psychological WPV.

Somatization disorder among adolescents in southeast Nigeria: a neglected issue.

BACKGROUND: Adolescents do present with somatization disorder which is often neglected by pediatricians. This could have serious consequences if not curbed early. OBJECTIVES: This study is aimed at determining the pattern and types of Somatization disorder among adolescents attending secondary schools in south east Nigeria. METHODS: Somatization disorder was investigated among 485 adolescents from mixed schools using a stratified random sampling of adolescents from four secondary schools in southeast Nigeria. The Enugu somatization scale was used to evaluate for presence of somatization in the participants. Statistical analysis was with statistical package for social sciences (SPPS) version 19 (Chicago IL). RESULTS: A total of 485 adolescents aged 10-19 years were included in this study. The mean age of the respondents was 16.36 with standard deviation (SD) of 3.14 years. Two hundred and fifty-one (51.8%) had head features, 262 (54.0%) had body features, 303 (62.5%) had either head or body features while 210 (43.3%) had both head and body features. One hundred and thirty-four males (51.3%) compared to 117 females (52.2%) reported symptoms consistent with head symptoms (p = 0.038). One hundred and eleven males (42.5%) compared to 99 females (44.2) reported symptoms related to the head and body (p = 0.137) while 135 males (51.7%) compared to 127 females (56.7%) reported symptoms related to the body (p = 0.925). There were significant associations of age in categories with head, body, either head or body as well as both head and body features (all p value <0.001). CONCLUSIONS: Psychosomatic problems do exist and may be on the rise among adolescents.

Assessing medical students' perception of effective teaching and learning in Nigerian medical school.

BACKGROUND: Medical education is always in a state of dynamic equilibrium with continuous evolution of new techniques in teaching and learning. OBJECTIVES: Objective of this study is to determine medical students' perception on preferences of teaching and learning. PARTICIPANTS: A total of 207 medical students participated in the study. Most (73.9%) of them were males while the modal age group was 23-25 years. Majority (57.5%) of the students belong the middle socioeconomic class and 65.7% resided within the hostel. RESULTS: Majority of the students (48.8%) believe two hours is enough to per lecture. Among the five different teaching-learning methods investigated, use of multimedia methods was found to be most effective. There exist a statistically significant association was found only in gender with regular oral examinations (Χ2 = 4.5, df = 1, p = 0.03) and socioeconomic class with dictation of lecture notes (Χ2 = 17.9, df = 9, p = 0.03). CONCLUSION: The present day medical student will end up as a good clinician if modern techniques of teaching and communication skills of the lecturers are adopted.

Behavioral disorder amongst adolescents attending secondary school in southeast Nigeria.

BACKGROUND: Adolescents are prone to various forms of behavioral problems. These behavioral issues in adolescents can have serious consequences for the adolescents. OBJECTIVES: The objectives of the study are to determine the causative factors of adolescent problems and specific manifestations. METHODS: Behavioral problems were investigated using a random sampling of adolescents from secondary schools in southeast Nigeria from February to April, 2014. A self-administered questionnaire was developed from Health Kids Colorado Questionnaire. RESULTS: A total of 763 subjects completed the questionnaire. Adolescents who reported to have used tobacco 3 to 5 and 6 to 9 times during the last 30 days are just 3.14% and 3.4%, respectively. Nineteen (2.49%) adolescents claimed that they have had sex before but not in the last 3 months. Adolescents who attempted suicide are from 15 years and peaked at 18. Eighty-three (11%) adolescents who are 15 years old attempted suicide in a year; this peaks at 17 years where 235 (30.8%) committed suicide. Majority of adolescents with behavioral disorder are from the upper class family. CONCLUSION: This study revealed that adolescents exhibit several forms of behavioral problems.

Attention deficit hyperactivity disorder: a neglected issue in the developing world.

BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is a neglected illness in a developing country. OBJECTIVES: The objectives of this study are to investigate the prevalence and pattern of ADHD among children in a Nigeria. METHODS: A structured self-administered questionnaire was used to collect information from the parents of children (and older children) who attended children outpatients' clinic during the study period. The DSM-IV-TR diagnostic criteria for attention deficit hyperactivity disorder were used. RESULTS: Two hundred and seventy-three (273) out of 282 questionnaires were filled completely, giving a response rate of 96.8%. Nine (9) children fulfilled the stated criteria for ADHD giving a prevalence rate of 3.2%. There is no association between gender and ADHD (P = 0.784). CONCLUSIONS: The prevalence of ADHD in our setting is 3.2%, which is similar to that obtained elsewhere in the world.